Browse GMC Sierra 2500HD Pickup Differential Axle Parts & GMC Sierra 2500HD Pickup Differential Auto Parts. Shop GMC Sierra 2500HD Pickup Differential Parts. Maintaining the differential parts of your GMC Sierra 2500HD Pickup is crucial for ensuring a smooth and controlled drive. Regular fluid checks and replacements can prevent wear and signal when a replacement is due, such as unusual noises or vibrations under your vehicle. When selecting new differential parts, consider the robustness of construction and the suitability for your driving demands, choosing from open, limited-slip, or locking differentials based on your typical terrain. High-quality materials like reinforced steel offer longevity and peace of mind, while professional installation ensures optimal performance. By investing in premium differential parts and committing to consistent maintenance, you'll extend the lifespan of your truck's drivetrain, enhancing both safety and efficiency.